Main
Chun-Hui Gao (高春辉)
Ph. D, Microbiology, bioinformatician, data scientist and useR.
I am broadly interested in the data mining, particularly integration and visualization, of biological, industrial and social datasets, which comes from high-throughput screening, Next-Generation Sequqncing (NGS), public databases and so on.
Work Experience
Post-doc Lecturer
College of Resources and Environment
Huazhong Agricultural University
current - 2016-3
Data Scientist
北京热心肠生物技术研究院有限公司
北京, 中国
2020-10 - 2019-11
Post-doctoral Fellow
School of Life Science
University of Science and Technology of China
2015-5 - 2013-2
Lecturer
School of Food and Biological Engineering
Hubei University of Technology
2012-12 - 2012-7
Education
PhD., Microbiology
Huazhong Agricultural University
Wuhan, CN
2012-6 - 2007-9
- Thesis: The characterization of a novel ArsR-type regulator in Mycobacterium tuberculosis and the characterization of molecular basis of isoniazid drug resistance in Mycobacteria
B. S., Biotechnology
Huazhong Agricultural University
Wuhan, CN
2008-7 - 2004-9
- bachelor-master continous program
The SCELSE Summer Course
Singapore Centre for Environmental Life Sciences Engineering
Singapore, SG
2016-7 - 2016-6
Research Summary
Professional Competence
Microbiology
- Transcriptional regulator
- Drug resistance
- Pathogenisis
- Persistance
Microbial ecology
- Social interaction
- Co-culture
- Multispecies biofilm
NGS
- (meta-)Genomics
- (meta-)RNA-seq
- Microbiome
- ChIP-seq
Bioinformatics
- Linux
- Perl
- R
Visualization
- ggplot2
- ggVennDiagram
- Reproducible research
Skills
- Write R package
- Statistics
- Illustration
- Bibliometric
- Data mining
Whole genome protein-protein and TF-promoter interactome in M. tuberculosis
College of Life Science and Technology
Huazhong Agricultural University
2007 - 2009
We used a bacterial two-hybrid method to construct the whole genome protein-protein interaction (PPI) network, and a bacterial one-hybrid method to construct the whole genome transcriptional regulator (TF) - promoter interaction network in M. tuberculosis.
Novel transcriptional regulator in mycobacteria
College of Life Science and Technology
Huazhong Agricultural University
2009 - 2012
- An ArsR-like transcriptional factor recognizes a conserved sequence motif and positively regulates the expression of phoP in mycobacteria
- A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis
- Characterization of a Novel ArsR-Like Regulator Encoded by Rv2034 in Mycobacterium tuberculosis
The intra-action between three RelBE modules and inter-action between RelBE3/SirR
College of Life Science and Technology
Huazhong Agricultural University
2009 - 2014
- Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules.
- Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358.
The regulation of secondary metabolite (ε-poly lysine) biosynthesis in Streptomyces albus ZPM
School of Life Science
University of Science and Technology of China
2013 - 2014
- Identification of genetic variations associated with epsilon-poly-lysine biosynthesis in Streptomyces albulus ZPM by genome sequencing.
The distribution of type III-A CRISPR-Cas system in Staphylococcus aureus clinical isolates
School of Life Science
University of Science and Technology of China
2014 - 2015
- Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus.
The regulatory mechanism of drug susceptibility in mycobacteria
State Key Laboratory of Agricultural Microbiology
Huazhong Agricultural University
2012 - 2019
- InbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG
- OxiR specifically responds to isoniazid and regulates isoniazid susceptibility in mycobacteria
- Cross-talk between the three furA orthologs in Mycobacterium smegmatis and the contribution to isoniazid resistance
Unearthing the mechanism of soil biofilms
College of Resources and Environment
Huazhong Agricultural University
2016 - 2021
- Bacillus subtilis biofilm development in the presence of soil clay minerals and iron oxides
- Co-culture of soil biofilm isolates enables the discovery of novel antibiotics
- Soil biofilms: microbial interactions, challenges, and advanced techniques for ex-situ characterization
- Impact of metal oxide nanoparticles on in vitro DNA amplification
Regulation of synthetic bacteria community
College of Resources and Environment
Huazhong Agricultural University
2016 - 2021
- The initial inoculation ratio regulates bacterial coculture interactions and metabolic capacity
- Emergent transcriptional adaption facilitates convergent succession within a synthetic community
- Divergent Influence to a Pathogen Invader by Resident Bacteria with Different Social Interactions
Grants
CNY ¥24(主持)
NSFC 青年科学基金
N/A
2024 - 2022
CNY ¥72.5(主持)
国家重点研发计划子课题
N/A
2021 - 2016
CNY ¥5(主持)
博士后基金面上项目
N/A
2016 - 2013
Teaching Experience
RNA-seq从入门到精通
华中农业大学暑期生物信息学培训班
武汉
2018-7
土壤微生物组
undergraduate students
Wuhan, CN
2018-5
土壤中的多物种生物膜
graduated students
Wuhan, CN
2016-12
Conferences
Oral presentations
二菌株合成菌群收敛演化的分子机制
土壤生物多样性与生物化学过程研讨会
安徽合肥
2021-6-24 - 2021-6-20
关于土壤健康,微生态研究给我带来的3个遐想
第二届土壤生物健康研讨会
海南兴隆
2020-12-27 - 2020-12-24
微生物之间的协作有利于细菌的存活和代谢
全国土壤生物生化与土壤健康学术研讨会
上海
2017
土壤生物膜的形成和群落演替
中国土壤学会第十三次全国会员代表大会
西安
2016
Conference abstract
Conference participation
第八届全国微生物基因组学学术研讨会
present
Wuhan, CN
2021-7-12 - 2021-7-10
中国肠道大会 2021
present
Nanjing, CN
2021-5-30 - 2021-5-28
深圳市合成生物产业发展研讨会
present
Shenzhen, CN
2019-6-14
中国肠道大会 2019
present
Beijing, CN
2019-5-6 - 2019-5-5
Sino-German Symposium on Microbiomics and Plant Health
present
Wuhan, CN
2018-9-24
“不忘初心,牢记使命”教工党员培训班
present
Shaoshan, CN
2018-11-25 - 2018-11-24
土壤微生物新理论新技术研讨会暨培训班
present
Nanjing, CN
2018-11-17 - 2018-11-15
School Honors
农业微生物学国家重点实验室优秀研究生
10 each year
Wuhan, CN
2012 - 2011
优秀毕业研究生
n.a.
Wuhan, CN
2012
三好研究生
n.a.
Wuhan, CN
2011 - 2010
三好研究生
n.a.
Wuhan, CN
2009 - 2008
优秀毕业生
5 out of 45
Wuhan, CN
2008
三好学生
10 out of 45
Wuhan, CN
2007 - 2006
优秀团员
5 out of 45
Wuhan, CN
2006 - 2005
三好学生
10 out of 45
Wuhan, CN
2005 - 2004
Publifications
- Citation = 928
- H-index = 17
- I10-index = 23
Book Chapter
平衡肠道微生态
《活出健康: 免疫力就是好医生》(王贵强,王立祥,张文宏主编), 2020
N/A
2020
- 高春辉; 蓝灿辉